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International Journal of Health and Rehabilitation Sciences

International Journal of Health and Rehabilitation Sciences
ISSN (online) : 2278-9030
ISSN (Print) : 2278-9014
ISSUES : 4/year
PUBLISHER : Rehabilitation Without Borders

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Original Research 


Vitamin E Improves Cognitive and Functional Activities in Old Rats

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed..

Abstract
Background: Aged humans and animals demonstrate cognitive decline. Improvement of short-term memory performance in aged beagles with a nutraceutical supplement containing phosphatidylserine (PS) and vitamin E has been demonstrated.
Objectives: The purpose of the present study was to examine if alpha-tocopherol acetate could alter PS metabolism in the hippocampus and to improve cognitive
Materials and methods: Intragastric administration of alpha-tocopherol acetate to 24-month-old rats for 14 days.
Results: Increase of newly synthesized PS level in the hippocampus of experimental animals as compared with control rats. At the same time, there was a decrease in [14C] phosphatidylcholine (PC) content in the hippocampus of experimental rats with respect to controls. The changes in phospholipids levels was seen in the hippocampus of experimental animals due to alpha-tocopherol acetate administration were associated with increased number of active avoidances and decreased latent period of avoidances on acquisition of a conditioned reflex in a shuttle box.
Conclusion: The data which was obtained in the work provide evidence that alpha-tocopherol acetate is a powerful modulator of phospholipids metabolism in the hippocampus and its function at old age.
Keywords: Aging, Hippocampus, Vitamin E, Phosphatidylcholine, Phosphatidylserine, Cognitive Function.

Key words: Aging, Hippocampus, Vitamin E, Phosphatidylcholine, Phosphatidylserine, Cognitive Function


 
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How to Cite this Article
Pubmed Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed.. Vitamin E Improves Cognitive and Functional Activities in Old Rats. IJHRS. 2017; 6(2): 77-89. doi:10.5455/ijhrs.0000000124


Web Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed.. Vitamin E Improves Cognitive and Functional Activities in Old Rats. http://www.ijhrs.org/?mno=302643312 [Access: June 18, 2021]. doi:10.5455/ijhrs.0000000124


AMA (American Medical Association) Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed.. Vitamin E Improves Cognitive and Functional Activities in Old Rats. IJHRS. 2017; 6(2): 77-89. doi:10.5455/ijhrs.0000000124



Vancouver/ICMJE Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed.. Vitamin E Improves Cognitive and Functional Activities in Old Rats. IJHRS. (2017), [cited June 18, 2021]; 6(2): 77-89. doi:10.5455/ijhrs.0000000124



Harvard Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed. (2017) Vitamin E Improves Cognitive and Functional Activities in Old Rats. IJHRS, 6 (2), 77-89. doi:10.5455/ijhrs.0000000124



Turabian Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed.. 2017. Vitamin E Improves Cognitive and Functional Activities in Old Rats. International Journal of Health and Rehabilitation Sciences (IJHRS), 6 (2), 77-89. doi:10.5455/ijhrs.0000000124



Chicago Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed.. "Vitamin E Improves Cognitive and Functional Activities in Old Rats." International Journal of Health and Rehabilitation Sciences (IJHRS) 6 (2017), 77-89. doi:10.5455/ijhrs.0000000124



MLA (The Modern Language Association) Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed.. "Vitamin E Improves Cognitive and Functional Activities in Old Rats." International Journal of Health and Rehabilitation Sciences (IJHRS) 6.2 (2017), 77-89. Print. doi:10.5455/ijhrs.0000000124



APA (American Psychological Association) Style

Loay Khaled Hassouneh, Salameh Al Dajah, Zead Helmi Abudayeh, Mai Adnan Abdullah, Wadie Abed. (2017) Vitamin E Improves Cognitive and Functional Activities in Old Rats. International Journal of Health and Rehabilitation Sciences (IJHRS), 6 (2), 77-89. doi:10.5455/ijhrs.0000000124



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