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International Journal of Health and Rehabilitation Sciences

International Journal of Health and Rehabilitation Sciences
ISSN (online) : 2278-9030
ISSN (Print) : 2278-9014
ISSUES : 4/year
PUBLISHER : Rehabilitation Without Borders

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Original Research 


Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh.

Abstract
Background: High-fat-diets could induce obesity, also leading to increase inflammation and insulin resistance
Purpose: The aim of this study was to examine weight gain, insulin sensitivity, and serum inflammatory biomarkers after feeding female rats different high-fat-diets for 6 weeks.
Materials and Methods: Eight weeks Sprague-Dawley female rats were randomly divided into three main dietary groups: rats were fed the high saturated fat diet group (HSFD; n=6), rats were fed the high monounsaturated fat diet group (HMUSFD; n=6) and rats were fed normal fat diet group (NFD) (n=6), for 6 weeks. Blood samples were collected; serum glucose, insulin, C- reactive protein (CRP), interleukin-6 (IL-6) and leptin were analyzed.
Results: Findings of this study demonstrated that no significant elevation in weight gain, FBG, insulin and HOMA-IR in rats that were fed HFDs as compared to rats that were fed NFD. Also, the inflammatory biomarkers that mentioned
(IL-6, leptin and CRP) did not significantly affected by feeding rats HFDs as compared to rats that were fed NFD.
Conclusion: High-fat-diets did not induce weight gain, insulin resistance and inflammation on female rats after short period of time.

Key words: high-fat-diet; insulin resistance; weight gain; leptin; IL-6; CRP


 
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Pubmed Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh. Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets. IJHRS. 2018; 7(1): 30-40. doi:10.5455/ijhrs.0000000140


Web Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh. Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets. http://www.ijhrs.org/?mno=297045 [Access: October 17, 2021]. doi:10.5455/ijhrs.0000000140


AMA (American Medical Association) Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh. Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets. IJHRS. 2018; 7(1): 30-40. doi:10.5455/ijhrs.0000000140



Vancouver/ICMJE Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh. Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets. IJHRS. (2018), [cited October 17, 2021]; 7(1): 30-40. doi:10.5455/ijhrs.0000000140



Harvard Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh (2018) Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets. IJHRS, 7 (1), 30-40. doi:10.5455/ijhrs.0000000140



Turabian Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh. 2018. Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets. International Journal of Health and Rehabilitation Sciences (IJHRS), 7 (1), 30-40. doi:10.5455/ijhrs.0000000140



Chicago Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh. "Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets." International Journal of Health and Rehabilitation Sciences (IJHRS) 7 (2018), 30-40. doi:10.5455/ijhrs.0000000140



MLA (The Modern Language Association) Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh. "Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets." International Journal of Health and Rehabilitation Sciences (IJHRS) 7.1 (2018), 30-40. Print. doi:10.5455/ijhrs.0000000140



APA (American Psychological Association) Style

Buthaina Alkhatib; Hayder Al-Domi; Basha’er Abu Irmaileh (2018) Female rats were protected against weight gain, insulin resistance and inflammation induced by high-fat-diets. International Journal of Health and Rehabilitation Sciences (IJHRS), 7 (1), 30-40. doi:10.5455/ijhrs.0000000140



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